Cristina Alvira, MD

Professor
Pediatrics
[email protected]
Publications: 

Loss of TRPV4 decreases NFκB-mediated myometrial inflammation and prevents preterm labor.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Ingles JA, Rodriguez Z, Fornes D, Ying L, Han X, Cornfield DN, Alvira CM

miR-203 modulates pregnant myometrium contractility via transient receptor potential vanilloid 4 channel expression.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Ying L, Fornes DD, Dobberfuhl AD, Ansari JR, Alvira CM, Cornfield DN

Pediatric subspecialty workforce: what is needed to secure its vitality and survival?

Pediatric research

Dammann CE, Alvira CM, Devaskar SU, St Geme JW, Golden WC, Gordon CM, Hoffmann B, Lakshminrusimha S, Leslie LK, Trent M, Winer KK, Fromme HB

Studying the Pulmonary Endothelium in Health and Disease: An Official American Thoracic Society Workshop Report.

American journal of respiratory cell and molecular biology

Hough RF, Alvira CM, Bastarache JA, Erzurum SC, Kuebler WM, Schmidt EP, Shimoda LA, Abman SH, Alvarez DF, Belvitch P, Bhattacharya J, Birukov KG, Chan SY, Cornfield DN, Dudek SM, Garcia JGN, Harrington EO, Hsia CCW, Islam MN, Jonigk DD, Kalinichenko VV, Kolb TM, Lee JY, Mammoto A, Mehta D, Rounds S, Schupp JC, Shaver CM, Suresh K, Tambe DT, Ventetuolo CE, Yoder MC, Stevens T, Damarla M

Seeing pulmonary hypertension through a paediatric lens: a viewpoint.

The European respiratory journal

Agarwal S, Fineman J, Cornfield DN, Alvira CM, Zamanian RT, Goss K, Yuan K, Bonnet S, Boucherat O, Pullamsetti S, Alcázar MA, Goncharova E, Kudryashova TV, Nicolls MR, de Jesús Pérez V

Hyperoxia prevents the dynamic neonatal increases in lung mesenchymal cell diversity.

Scientific reports

Zanini F, Che X, Suresh NE, Knutsen C, Klavina P, Xie Y, Domingo-Gonzalez R, Liu M, Kum A, Jones RC, Quake SR, Alvira CM, Cornfield DN

Integrative analysis of noncoding mutations identifies the druggable genome in preterm birth.

Science advances

Wang C, Wang YJ, Ying L, Wong RJ, Quaintance CC, Hong X, Neff N, Wang X, Biggio JR, Mesiano S, Quake SR, Alvira CM, Cornfield DN, Stevenson DK, Shaw GM, Li J

CXCL10 deficiency limits macrophage infiltration, preserves lung matrix, and enables lung growth in bronchopulmonary dysplasia.

Inflammation and regeneration

Hirani DV, Thielen F, Mansouri S, Danopoulos S, Vohlen C, Haznedar-Karakaya P, Mohr J, Wilke R, Selle J, Grosch T, Mizik I, Odenthal M, Alvira CM, Kuiper-Makris C, Pryhuber GS, Pallasch C, van Koningsbruggen-Rietschel S, Al-Alam D, Seeger W, Savai R, Dötsch J, Alejandre Alcazar MA

Loss of prolyl hydroxylase 1 and 2 in SM22α-expressing cells prevents Hypoxia-Induced pulmonary hypertension.

American journal of physiology. Lung cellular and molecular physiology

Barnes EA, Ito R, Che X, Alvira CM, Cornfield DN

Hypoxia-Inducible Factor-1α in SM22α-Expressing Cells Modulates Alveolarization.

American journal of respiratory cell and molecular biology

Barnes EA, Knutsen C, Kindt A, Che X, Ying L, Adams E, Gonzalez E, Oak P, Hilgendorff A, Alvira CM, Cornfield DN

Endothelial-specific loss of IKKβ disrupts pulmonary endothelial angiogenesis and impairs postnatal lung growth.

American journal of physiology. Lung cellular and molecular physiology

Rao S, Liu M, Iosef C, Knutsen C, Alvira CM

Wnt7a deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension.

The European respiratory journal

Chakraborty A, Nathan A, Orcholski M, Agarwal S, Shamskhou EA, Auer N, Mitra A, Guardado ES, Swaminathan G, Condon DF, Yu J, McCarra M, Juul NH, Mallory A, Guzman-Hernandez RA, Yuan K, Rojas V, Crossno JT, Yung LM, Yu PB, Spencer T, Winn RA, Frump A, Karoor V, Lahm T, Hedlin H, Fineman JR, Lafyatis R, Knutsen CNF, Alvira CM, Cornfield DN, de Jesus Perez VA

Developmental diversity and unique sensitivity to injury of lung endothelial subtypes during postnatal growth.

iScience

Zanini F, Che X, Knutsen C, Liu M, Suresh NE, Domingo-Gonzalez R, Dou SH, Zhang D, Pryhuber GS, Jones RC, Quake SR, Cornfield DN, Alvira CM

SM22α cell-specific HIF stabilization mitigates hyperoxia-induced neonatal lung injury.

American journal of physiology. Lung cellular and molecular physiology

Ito R, Barnes EA, Che X, Alvira CM, Cornfield DN

Macrophage-derived IL-6 trans-signalling as a novel target in the pathogenesis of bronchopulmonary dysplasia.

The European respiratory journal

Hirani D, Alvira CM, Danopoulos S, Milla C, Donato M, Tian L, Mohr J, Dinger K, Vohlen C, Selle J, V Koningsbruggen-Rietschel S, Barbarino V, Pallasch C, Rose-John S, Odenthal M, Pryhuber GS, Mansouri S, Savai R, Seeger W, Khatri P, Al Alam D, Dötsch J, Alejandre Alcazar MA

Dynamism of the Human Lung Proteome during Alveolarization: Moving beyond the Transcriptome.

American journal of respiratory and critical care medicine

Alvira CM

Transforming Growth Factor-induced Protein Promotes NF-κB-mediated Angiogenesis during Postnatal Lung Development.

American journal of respiratory cell and molecular biology

Liu M, Iosef C, Rao S, Domingo-Gonzalez R, Fu S, Snider P, Conway SJ, Umbach GS, Heilshorn SC, Dewi RE, Dahl MJ, Null DM, Albertine KH, Alvira CM

Nanoparticle Delivery of Angiogenic Gene Therapy. Save the Vessels, Save the Lung!

American journal of respiratory and critical care medicine

Zepp JA, Alvira CM

Diverse homeostatic and immunomodulatory roles of immune cells in the developing mouse lung at single cell resolution.

eLife

Domingo-Gonzalez R, Zanini F, Che X, Liu M, Jones RC, Swift MA, Quake SR, Cornfield DN, Alvira CM

NF-κB/NKILA signaling modulates the anti-cancerous effects of EZH2 inhibition.

Journal of cellular and molecular medicine

Duan S, Chan WK, Oman A, Basile DP, Alvira CM, Buxton ILO, Iosef C

Enhancing the Development and Retention of Physician-Scientists in Academic Pediatrics: Strategies for Success.

The Journal of pediatrics

Alvira CM, Steinhorn RH, Balistreri WF, Fineman JR, Oishi PE, Padbury JF, Kinsella JP, Abman SH

Distinct roles for IκB kinases alpha and beta in regulating pulmonary endothelial angiogenic function during late lung development.

Journal of cellular and molecular medicine

Iosef C, Liu M, Ying L, Rao SP, Concepcion KR, Chan WK, Oman A, Alvira CM

Pulmonary artery smooth muscle cell HIF-1α regulates endothelin expression via microRNA-543.

American journal of physiology. Lung cellular and molecular physiology

Wang CC, Ying L, Barnes EA, Adams ES, Kim FY, Engel KW, Alvira CM, Cornfield DN

Intrauterine growth restriction decreases NF-κB signaling in fetal pulmonary artery endothelial cells of fetal sheep.

American journal of physiology. Lung cellular and molecular physiology

Dodson RB, Powers KN, Gien J, Rozance PJ, Seedorf G, Astling D, Jones K, Crombleholme TM, Abman SH, Alvira CM

β1-Subunit of the calcium-sensitive potassium channel modulates the pulmonary vascular smooth muscle cell response to hypoxia.

American journal of physiology. Lung cellular and molecular physiology

Barnes EA, Lee L, Barnes SL, Brenner R, Alvira CM, Cornfield DN

Developmental differences in focal adhesion kinase expression modulate pulmonary endothelial barrier function in response to inflammation.

American journal of physiology. Lung cellular and molecular physiology

Ying L, Alvira CM, Cornfield DN

Can We Understand the Pathobiology of Bronchopulmonary Dysplasia?

The Journal of pediatrics

Alvira CM, Morty RE

Long-term miR-29b suppression reduces aneurysm formation in a Marfan mouse model.

Physiological reports

Okamura H, Emrich F, Trojan J, Chiu P, Dalal AR, Arakawa M, Sato T, Penov K, Koyano T, Pedroza A, Connolly AJ, Rabinovitch M, Alvira C, Fischbein MP

Absence of TNF-α enhances inflammatory response in the newborn lung undergoing mechanical ventilation.

American journal of physiology. Lung cellular and molecular physiology

Ehrhardt H, Pritzke T, Oak P, Kossert M, Biebach L, Förster K, Koschlig M, Alvira CM, Hilgendorff A

Loss of PPARγ in endothelial cells leads to impaired angiogenesis.

Journal of cell science

Vattulainen-Collanus S, Akinrinade O, Li M, Koskenvuo M, Li CG, Rao SP, de Jesus Perez V, Yuan K, Sawada H, Koskenvuo JW, Alvira C, Rabinovitch M, Alastalo TP

The transient receptor potential vanilloid 4 channel modulates uterine tone during pregnancy.

Science translational medicine

Ying L, Becard M, Lyell D, Han X, Shortliffe L, Husted CI, Alvira CM, Cornfield DN

Activation of the nuclear factor-κB pathway during postnatal lung inflammation preserves alveolarization by suppressing macrophage inflammatory protein-2.

American journal of physiology. Lung cellular and molecular physiology

Hou Y, Liu M, Husted C, Chen C, Thiagarajan K, Johns JL, Rao SP, Alvira CM

Pulmonary artery smooth muscle cell endothelin-1 expression modulates the pulmonary vascular response to chronic hypoxia.

American journal of physiology. Lung cellular and molecular physiology

Kim FY, Barnes EA, Ying L, Chen C, Lee L, Alvira CM, Cornfield DN

Enhanced caspase activity contributes to aortic wall remodeling and early aneurysm development in a murine model of Marfan syndrome.

Arteriosclerosis, thrombosis, and vascular biology

Emrich FC, Okamura H, Dalal AR, Penov K, Merk DR, Raaz U, Hennigs JK, Chin JT, Miller MO, Pedroza AJ, Craig JK, Koyano TK, Blankenberg FG, Connolly AJ, Mohr FW, Alvira CM, Rabinovitch M, Fischbein MP

Haemophagocytic lymphohistiocytosis associated with coccidiomycosis.

BMJ case reports

Ramsi M, Alvira C, Purohit P, Cornfield D

Nuclear factor-kappa-B signaling in lung development and disease: one pathway, numerous functions.

Birth defects research. Part A, Clinical and molecular teratology

Alvira CM

Chronic lung disease in the preterm infant. Lessons learned from animal models.

American journal of respiratory cell and molecular biology

Hilgendorff A, Reiss I, Ehrhardt H, Eickelberg O, Alvira CM

Voltage-dependent anion channel-2 interaction with nitric oxide synthase enhances pulmonary artery endothelial cell nitric oxide production.

American journal of respiratory cell and molecular biology

Alvira CM, Umesh A, Husted C, Ying L, Hou Y, Lyu SC, Nowak J, Cornfield DN

Inhibiting NF-κB in the developing lung disrupts angiogenesis and alveolarization.

American journal of physiology. Lung cellular and molecular physiology

Iosef C, Alastalo TP, Hou Y, Chen C, Adams ES, Lyu SC, Cornfield DN, Alvira CM

Hypoxia-inducible factor-1α regulates KCNMB1 expression in human pulmonary artery smooth muscle cells.

American journal of physiology. Lung cellular and molecular physiology

Ahn YT, Kim YM, Adams E, Lyu SC, Alvira CM, Cornfield DN

miR-29b participates in early aneurysm development in Marfan syndrome.

Circulation research

Merk DR, Chin JT, Dake BA, Maegdefessel L, Miller MO, Kimura N, Tsao PS, Iosef C, Berry GJ, Mohr FW, Spin JM, Alvira CM, Robbins RC, Fischbein MP

Neutrophil elastase is produced by pulmonary artery smooth muscle cells and is linked to neointimal lesions.

The American journal of pathology

Kim YM, Haghighat L, Spiekerkoetter E, Sawada H, Alvira CM, Wang L, Acharya S, Rodriguez-Colon G, Orton A, Zhao M, Rabinovitch M

Inhibition of transforming growth factor β worsens elastin degradation in a murine model of Kawasaki disease.

The American journal of pathology

Alvira CM, Guignabert C, Kim YM, Chen C, Wang L, Duong TT, Yeung RS, Li DY, Rabinovitch M

Rho kinase modulates postnatal adaptation of the pulmonary circulation through separate effects on pulmonary artery endothelial and smooth muscle cells.

American journal of physiology. Lung cellular and molecular physiology

Alvira CM, Sukovich DJ, Lyu SC, Cornfield DN

Prolonged mechanical ventilation with air induces apoptosis and causes failure of alveolar septation and angiogenesis in lungs of newborn mice.

American journal of physiology. Lung cellular and molecular physiology

Mokres LM, Parai K, Hilgendorff A, Ertsey R, Alvira CM, Rabinovitch M, Bland RD

Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization.

American journal of physiology. Lung cellular and molecular physiology

Guignabert C, Alvira CM, Alastalo TP, Sawada H, Hansmann G, Zhao M, Wang L, El-Bizri N, Rabinovitch M

LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor.

Journal of cell science

Ying L, Lau A, Alvira CM, West R, Cann GM, Zhou B, Kinnear C, Jan E, Sarnow P, Van de Rijn M, Rabinovitch M

An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension.

The Journal of clinical investigation

Hansmann G, de Jesus Perez VA, Alastalo TP, Alvira CM, Guignabert C, Bekker JM, Schellong S, Urashima T, Wang L, Morrell NW, Rabinovitch M

Reactivation of gammaHV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin.

American journal of physiology. Lung cellular and molecular physiology

Spiekerkoetter E, Alvira CM, Kim YM, Bruneau A, Pricola KL, Wang L, Ambartsumian N, Rabinovitch M

Mechanical ventilation uncouples synthesis and assembly of elastin and increases apoptosis in lungs of newborn mice. Prelude to defective alveolar septation during lung development?

American journal of physiology. Lung cellular and molecular physiology

Bland RD, Ertsey R, Mokres LM, Xu L, Jacobson BE, Jiang S, Alvira CM, Rabinovitch M, Shinwell ES, Dixit A

Nuclear factor-kappaB activation in neonatal mouse lung protects against lipopolysaccharide-induced inflammation.

American journal of respiratory and critical care medicine

Alvira CM, Abate A, Yang G, Dennery PA, Rabinovitch M

Affiliation: 
Committee Members