Sanjeev Datar, MD, PhD | previewpscdp

Professor, Pediatrics

Associate Director

Physician-Scientist Career Development Program (PSCDP)

+1 415 502-6391

Dr. Sanjeev Datar is a critical care specialist who cares for children in the intensive care units, including cardiac intensive care. Dr. Datar's research, which is funded by the National Institutes of Health, is focused on better understanding how the lymphatic vasculature works in health and disease. Specifically, he is studying new ways to support and improve lymphatic function in the lungs of patients with congenital heart disease.

Datar earned his medical degree at the University of Washington and a doctorate in molecular and cellular biology in UW's joint program with Fred Hutchinson Cancer Research Center. He completed a residency in pediatrics and a fellowship in pediatric critical care medicine at UCSF, joining the faculty in 2008.

Dr. Datar has received a variety of honors, including the 2007 Charlotte Rose Coleman – Fry Award for pediatric critical care fellows, an Excellence in Teaching Award in 2012 from the UCSF Haile T. Debas Academy of Medical Educators, a Beginning Grant-in-Aid Award in 2012 from the American Heart Association and most recently the Ida M. Cannon for integrity from the Society for Social Work Leadership in Health Care. He is a member of the Society for Pediatric Research, Pulmonary Vascular Research Institute and Lymphatic Education & Research Network.

Publications

MicroRNA Profiling to Inform Disease Classification, Severity, and Treatment Response in Pediatric Pulmonary Hypertension.

American journal of physiology. Heart and circulatory physiology

Smith MA, Chiacchia S, Boehme J, Datar SA, Morell E, Keller RL, Romer A, Colglazier E, Parker C, Becerra J, Fineman JR

The mitochondrial redistribution of ENOS is regulated by AKT1 and dimer status.

Nitric oxide : biology and chemistry

Sun X, Moreno Caceres S, Yegambaram M, Lu Q, Pokharel MD, Boehme JT, Datar SA, Aggarwal S, Wang T, Fineman JR, Black SM

OMX: A NOVEL OXYGEN DELIVERY BIOTHERAPEUTIC IMPROVES OUTCOMES IN AN OVINE MODEL OF CONTROLLED HEMORRHAGIC SHOCK.

Shock (Augusta, Ga.)

Maltepe E, Smith M, Boehme J, Datar SA, Hutchings RS, Vento CA, Manzoor H, Loucks A, Winger JA, Fineman JR

1180: PULMONARY PULSE WAVE ANALYSIS: A NOVEL MODEL TO IDENTIFY VASCULAR INJURY IN PULMONARY HYPERTENSION.

Critical Care Medicine

Youssef Ahmed, Stephen Bennett, Jason Boehme, David Teitel, Jeffrey Fineman, Sanjeev Datar

Simvastatin restores pulmonary endothelial function in the setting of pulmonary over-circulation.

Nitric oxide : biology and chemistry

Boehme JT, Sun X, Lu Q, Barton J, Wu X, Gong W, Raff GW, Datar SA, Wang T, Fineman JR, Black SM

445 Awardee Talk: Generation of a BMPR2 Heterozygous Ovine Genetic Model for Heritable Pulmonary Arterial Hypertension.

Journal of Animal Science

Austin R Brown, Devon Fitzpatrick, Sanjeev Datar, Thomas F Bishop, Alison L Van Eenennaam

Respiratory mechanics and gas exchange in an ovine model of congenital heart disease with increased pulmonary blood flow and pressure.

Frontiers in physiology

Soares JHN, Raff GW, Fineman JR, Datar SA

HIF-1α promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow.

Scientific reports

Boehme JT, Morris CJ, Chiacchia SR, Gong W, Wu KY, Kameny RJ, Raff GW, Fineman JR, Maltepe E, Datar SA

Mechanical forces alter endothelin-1 signaling: comparative ovine models of congenital heart disease.

Pulmonary circulation

Zhu T, Chiacchia S, Kameny RJ, Garcia De Herreros A, Gong W, Raff GW, Boehme JB, Maltepe E, Lasheras JC, Black SM, Datar SA, Fineman JR

Mechanical Forces Alter Endothelin-1 Signaling: Comparative Ovine Models of Congenital Heart Disease.

Biophysical Journal

Antoni Garcia-Herreros, Rebecca J. Kameny, Terry Zhu, Jason Boehme, Gary Raff, Juan C. Lasheras, Stephen M. Black, Emin Maltepe, Sanjeev A. Datar, Jeffrey R. Fineman

The Adaptive Right Ventricle in Eisenmenger Syndrome: Potential Therapeutic Targets for Pulmonary Hypertension?.

Rebecca Johnson Kameny, Sanjeev A. Datar, Jason Boehme, Jeffrey R. Fineman

Ovine Models of Congenital Heart Disease and the Consequences of Hemodynamic Alterations for Pulmonary Artery Remodeling.

American journal of respiratory cell and molecular biology

Johnson Kameny R, Datar SA, Boehme JB, Morris C, Zhu T, Goudy BD, Johnson EG, Galambos C, Raff GW, Sun X, Wang T, Chiacchia SR, Lu Q, Black SM, Maltepe E, Fineman JR

Correction: Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic.

PLoS biology

Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, Krtolica A, Maltepe E

Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic.

PLoS biology

Analysis of the microRNA signature driving adaptive right ventricular hypertrophy in an ovine model of congenital heart disease.

American journal of physiology. Heart and circulatory physiology

Kameny RJ, He Y, Zhu T, Gong W, Raff GW, Chapin CJ, Datar SA, Boehme JT, Hata A, Fineman JR

Lymphatic dysfunction in critical illness.

Current opinion in pediatrics

Burke E, Datar SA

KLF2-mediated disruption of PPAR-γ signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow.

American journal of physiology. Heart and circulatory physiology

Morris CJ, Kameny RJ, Boehme J, Gong W, He Y, Zhu T, Maltepe E, Raff GW, Fineman JR, Datar SA

Altered Carnitine Homeostasis in Children With Increased Pulmonary Blood Flow Due to Ventricular Septal Defects.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Black SM, Field-Ridley A, Sharma S, Kumar S, Keller RL, Kameny R, Maltepe E, Datar SA, Fineman JR

Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation.

American journal of physiology. Heart and circulatory physiology

Boehme J, Sun X, Tormos KV, Gong W, Kellner M, Datar SA, Kameny RJ, Yuan JX, Raff GW, Fineman JR, Black SM, Maltepe E

Disrupted NOS signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow.

American journal of physiology. Heart and circulatory physiology

Datar SA, Gong W, He Y, Johengen M, Kameny RJ, Raff GW, Maltepe E, Oishi PE, Fineman JR

Right ventricular nitric oxide signaling in an ovine model of congenital heart disease: a preserved fetal phenotype.

American journal of physiology. Heart and circulatory physiology

Kameny RJ, He Y, Morris C, Sun C, Johengen M, Gong W, Raff GW, Datar SA, Oishi PE, Fineman JR

162.

Critical Care Medicine

Jun Maki, Rebecca Johnson, Sanjeev Datar, Wenhui Gong, Michael Johengen, Christine Sun, Peter Oishi, Jeffrey Fineman

220.

Critical Care Medicine

Rebecca Kameny, Catherine Morris, Youping He, Christine Sun, Jun Maki, Sanjeev Datar, Peter Oishi, Jeffrey Fineman

Sox18 preserves the pulmonary endothelial barrier under conditions of increased shear stress.

Journal of cellular physiology

Gross CM, Aggarwal S, Kumar S, Tian J, Kasa A, Bogatcheva N, Datar SA, Verin AD, Fineman JR, Black SM

Adaptive right ventricular performance in response to acutely increased afterload in a lamb model of congenital heart disease: evidence for enhanced Anrep effect.

American journal of physiology. Heart and circulatory physiology

Johnson RC, Datar SA, Oishi PE, Bennett S, Maki J, Sun C, Johengen M, He Y, Raff GW, Redington AN, Fineman JR

Altered reactivity and nitric oxide signaling in the isolated thoracic duct from an ovine model of congenital heart disease with increased pulmonary blood flow.

American journal of physiology. Heart and circulatory physiology

Datar SA, Oishi PE, Gong W, Bennett SH, Sun CE, Johengen M, Maki J, Johnson RC, Raff GW, Fineman JR

Pulmonary Hypertension.

Pediatric Critical Care Medicine

Peter Oishi, Sanjeev A. Datar, Jeffrey R. Fineman

Preoperative B-type natriuretic peptide levels are associated with outcome after total cavopulmonary connection (Fontan).

The Journal of thoracic and cardiovascular surgery

Radman M, Keller RL, Oishi P, Datar SA, Wellnitz K, Azakie A, Hanley F, Char D, Hsu JH, Amrinovin R, Adatia I, Fineman JR

L-carnitine preserves endothelial function in a lamb model of increased pulmonary blood flow.

Pediatric research

Sharma S, Aramburo A, Rafikov R, Sun X, Kumar S, Oishi PE, Datar SA, Raff G, Xoinis K, Kalkan G, Fratz S, Fineman JR, Black SM

The effect of preoperative nutritional status on postoperative outcomes in children undergoing surgery for congenital heart defects in San Francisco (UCSF) and Guatemala City (UNICAR).

The Journal of thoracic and cardiovascular surgery

Radman M, Mack R, Barnoya J, Castañeda A, Rosales M, Azakie A, Mehta N, Keller R, Datar S, Oishi P, Fineman J

Tezosentan increases nitric oxide signaling via enhanced hydrogen peroxide generation in lambs with surgically induced acute increases in pulmonary blood flow.

Journal of cellular biochemistry

Kumar S, Oishi PE, Rafikov R, Aggarwal S, Hou Y, Datar SA, Sharma S, Azakie A, Fineman JR, Black SM

Chronic inhibition of PPAR-γ signaling induces endothelial dysfunction in the juvenile lamb.

Pulmonary pharmacology & therapeutics

Sharma S, Barton J, Rafikov R, Aggarwal S, Kuo HC, Oishi PE, Datar SA, Fineman JR, Black SM

Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow.

Pediatric research

Oishi PE, Sharma S, Datar SA, Kumar S, Aggarwal S, Lu Q, Raff G, Azakie A, Hsu JH, Sajti E, Fratz S, Black SM, Fineman JR

Endostatin, an inhibitor of angiogenesis, decreases after bidirectional superior cavopulmonary anastamosis.

Pediatric cardiology

Field-Ridley A, Heljasvaara R, Pihlajaniemi T, Adatia I, Sun C, Keller RL, Gong WH, Datar S, Oishi P, Fineman JR

PPAR-γ regulates carnitine homeostasis and mitochondrial function in a lamb model of increased pulmonary blood flow.

PloS one

Sharma S, Sun X, Rafikov R, Kumar S, Hou Y, Oishi PE, Datar SA, Raff G, Fineman JR, Black SM

B-type natriuretic peptide levels predict outcomes in infants undergoing cardiac surgery in a lesion-dependent fashion.

The Journal of thoracic and cardiovascular surgery

Amirnovin R, Keller RL, Herrera C, Hsu JH, Datar S, Karl TR, Adatia I, Oishi P, Fineman JR

Pulmonary interstitial glycogenosis: an unrecognized etiology of persistent pulmonary hypertension of the newborn in congenital heart disease?

Pediatric cardiology

Radman MR, Goldhoff P, Jones KD, Azakie A, Datar S, Adatia I, Oishi PE, Fineman JR

B-Type Natriuretic Peptide (BNP) in Neonates, Infants and Children Undergoing Cardiac Surgery.

Front Lines of Thoracic Surgery

Peter E. Oishi, Aida Field-Ridley, Sanjeev A. Datar, Jeffrey R. Fineman

Altered lymphatics in an ovine model of congenital heart disease with increased pulmonary blood flow.

American journal of physiology. Lung cellular and molecular physiology

Datar SA, Johnson EG, Oishi PE, Johengen M, Tang E, Aramburo A, Barton J, Kuo HC, Bennett S, Xoinis K, Reel B, Kalkan G, Sajti E, Osorio O, Raff GW, Matthay MA, Fineman JR

Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration.

Journal of cellular physiology

Aggarwal S, Gross CM, Kumar S, Datar S, Oishi P, Kalkan G, Schreiber C, Fratz S, Fineman JR, Black SM

Advances in the management of pediatric pulmonary hypertension.

Respiratory care

Oishi P, Datar SA, Fineman JR

Pediatric pulmonary arterial hypertension: current and emerging therapeutic options.

Expert opinion on pharmacotherapy

Oishi P, Datar SA, Fineman JR

Delineating the angiogenic gene expression profile before pulmonary vascular remodeling in a lamb model of congenital heart disease.

Physiological genomics

Tian J, Fratz S, Hou Y, Lu Q, Görlach A, Hess J, Schreiber C, Datar SA, Oishi P, Nechtman J, Podolsky R, She JX, Fineman JR, Black SM

Nitric oxide alterations following acute ductal constriction in the fetal lamb: a role for superoxide.

American journal of physiology. Lung cellular and molecular physiology

Hsu JH, Oishi P, Wiseman DA, Hou Y, Chikovani O, Datar S, Sajti E, Johengen MJ, Harmon C, Black SM, Fineman JR

Alterations in lung arginine metabolism in lambs with pulmonary hypertension associated with increased pulmonary blood flow.

Vascular pharmacology

Sharma S, Kumar S, Sud N, Wiseman DA, Tian J, Rehmani I, Datar S, Oishi P, Fratz S, Venema RC, Fineman JR, Black SM

A CAUSAL DESIGN TRAJECTORY LINKS DIVERSE FORMS OF PULMONARY HYPERTENSION: EVIDENCE OF A FETAL PHENOTYPE OF ARTERIAL REMODELING UNDER THE PRINCIPLE OF MINIMUM WORK.

CHEST Journal

Roblee P. Allen, Gary Raff, Sanjeev Datar, Anita Moon, Jay M. Milstein, Stephen H. Bennett, Stephen M. Black, Jeffery R. Fineman, Marlowe W. Eldridge

Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress.

American journal of physiology. Lung cellular and molecular physiology

Oishi PE, Wiseman DA, Sharma S, Kumar S, Hou Y, Datar SA, Azakie A, Johengen MJ, Harmon C, Fratz S, Fineman JR, Black SM

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