
Professor and Chief
M_MED-ZSFG-EXPM
The goal of my research is to provide the mechanistic basis for development of effective vaccines against tuberculosis.
Publications
Plasma proteomics for novel biomarker discovery in childhood tuberculosis.
medRxiv : the preprint server for health sciences
CCR2 recruits monocytes to the lung, while CX3CR1 modulates positioning of monocyte-derived CD11c pos cells in the lymph node during pulmonary tuberculosis.
bioRxiv : the preprint server for biology
Tax1bp1 enhances bacterial virulence and promotes inflammatory responses during Mycobacterium tuberculosis infection of alveolar macrophages.
bioRxiv : the preprint server for biology
Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction.
bioRxiv : the preprint server for biology
Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection.
PLoS pathogens
High-parameter phenotypic characterization reveals a subset of human Th17 cells that preferentially produce IL-17 against M. tuberculosis antigen.
Frontiers in immunology
M. tuberculosis antigen-responsive IL17 + CD4 T cells are disproportionately spared in ART-suppressed HIV.
bioRxiv : the preprint server for biology
Rare Variable M. tuberculosis Antigens induce predominant Th17 responses in human infection.
bioRxiv : the preprint server for biology
A teenage girl with altered mental status and paraparesis.
Journal of clinical tuberculosis and other mycobacterial diseases
Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection.
Research square
Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during persistent infection.
bioRxiv : the preprint server for biology
Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania.
PLoS pathogens
Spatial mapping reveals granuloma diversity and histopathological superstructure in human tuberculosis.
The Journal of experimental medicine
Circularization of rv0678 for Genotypic Bedaquiline Resistance Testing of Mycobacterium tuberculosis.
Microbiology spectrum
High-resolution imaging of protein secretion at the single-cell level using plasmon-enhanced FluoroDOT assay.
Cell reports methods
Repeated Plasmodium falciparum infection in humans drives the clonal expansion of an adaptive γδ T cell repertoire.
Science translational medicine
A Framework to Identify Antigen-Expanded T Cell Receptor Clusters Within Complex Repertoires.
Frontiers in immunology
A defective viral genome strategy elicits broad protective immunity against respiratory viruses.
Cell
Toward Comprehensive Plasma Proteomics by Orthogonal Protease Digestion.
Journal of proteome research
Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease.
Nature immunology
Efficient generation of isogenic primary human myeloid cells using CRISPR-Cas9 ribonucleoproteins.
Cell reports
Schistosoma mansoni Infection Is Associated With a Higher Probability of Tuberculosis Disease in HIV-Infected Adults in Kenya.
Journal of acquired immune deficiency syndromes (1999)
Evaluation of SARS-CoV-2 serology assays reveals a range of test performance.
Nature biotechnology
Test performance evaluation of SARS-CoV-2 serological assays.
medRxiv : the preprint server for health sciences
Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barré Syndrome in Brazil.
PLoS neglected tropical diseases
Mononuclear cell dynamics in M. tuberculosis infection provide opportunities for therapeutic intervention.
PLoS pathogens
Limited Antimycobacterial Efficacy of Epitope Peptide Administration Despite Enhanced Antigen-Specific CD4 T-Cell Activation.
The Journal of infectious diseases
Mechanisms of M. tuberculosis Immune Evasion as Challenges to TB Vaccine Design.
Cell host & microbe
Float Like Bacilli, STING Like a B: Type I Interferons in Tuberculosis.
American journal of respiratory and critical care medicine
A High Throughput Whole Blood Assay for Analysis of Multiple Antigen-Specific T Cell Responses in Human Mycobacterium tuberculosis Infection.
Journal of immunology (Baltimore, Md. : 1950)
Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 100 Luo infants from the Boro area of Nyanza Province, Kenya.
Human immunology
Antigenic Variation and Immune Escape in the MTBC.
Advances in experimental medicine and biology
Within Host Evolution Selects for a Dominant Genotype of Mycobacterium tuberculosis while T Cells Increase Pathogen Genetic Diversity.
PLoS pathogens
Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent CD4+ T-cell activation.
Nature microbiology
Type I Interferon is Pathogenic During Chronic Mycobacterium africanum Infection.
The Journal of infectious diseases
The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-Dependent.
PLoS pathogens
Antigen Export Reduces Antigen Presentation and Limits T Cell Control of M. tuberculosis.
Cell host & microbe
Correction: LprG-Mediated Surface Expression of Lipoarabinomannan Is Essential for Virulence of Mycobacterium tuberculosis.
PLoS pathogens
Suboptimal Antigen Presentation Contributes to Virulence of Mycobacterium tuberculosis In Vivo.
Journal of immunology (Baltimore, Md. : 1950)
M. tuberculosis T Cell Epitope Analysis Reveals Paucity of Antigenic Variation and Identifies Rare Variable TB Antigens.
Cell host & microbe
STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection.
The Journal of clinical investigation
In vivo biosynthesis of terpene nucleosides provides unique chemical markers of Mycobacterium tuberculosis infection.
Chemistry & biology
Beyond macrophages: the diversity of mononuclear cells in tuberculosis.
Immunological reviews
LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis.
PLoS pathogens
Cell-to-cell transfer of M. tuberculosis antigens optimizes CD4 T cell priming.
Cell host & microbe
Cutting edge: Direct recognition of infected cells by CD4 T cells is required for control of intracellular Mycobacterium tuberculosis in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Taking sides: interferons in leprosy.
Cell host & microbe
CD4+ T cell-dependent IFN-γ production by CD8+ effector T cells in Mycobacterium tuberculosis infection.
Journal of immunology (Baltimore, Md. : 1950)
The immunological life cycle of tuberculosis.
Nature reviews. Immunology
Meeting report: The International Conference on Human Immunity to Tuberculosis.
Tuberculosis (Edinburgh, Scotland)
Dynamic roles of type I and type II IFNs in early infection with Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950)
Impaired fitness of Mycobacterium africanum despite secretion of ESAT-6.
The Journal of infectious diseases
Mycobacterium tuberculosis inhibits neutrophil apoptosis, leading to delayed activation of naive CD4 T cells.
Cell host & microbe
Tuberculosis pathogenesis and immunity.
Annual review of pathology
Suboptimal activation of antigen-specific CD4+ effector cells enables persistence of M. tuberculosis in vivo.
PLoS pathogens
Lung neutrophils facilitate activation of naive antigen-specific CD4+ T cells during Mycobacterium tuberculosis infection.
Journal of immunology (Baltimore, Md. : 1950)
HIV and tuberculosis: a deadly human syndemic.
Clinical microbiology reviews
Initiation and regulation of T-cell responses in tuberculosis.
Mucosal immunology
Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved.
Nature genetics
Ectopic activation of Mycobacterium tuberculosis-specific CD4+ T cells in lungs of CCR7-/- mice.
Journal of immunology (Baltimore, Md. : 1950)
Lipoprotein processing is essential for resistance of Mycobacterium tuberculosis to malachite green.
Antimicrobial agents and chemotherapy
Anti-TNF immunotherapy and tuberculosis reactivation: another mechanism revealed.
The Journal of clinical investigation
RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteins.
Cell host & microbe
CO-opting the host HO-1 pathway in tuberculosis and malaria.
Cell host & microbe
Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs.
The Journal of experimental medicine
Meeting Report: NIH Workshop on the Tuberculosis Immune Epitope Database.
Tuberculosis (Edinburgh, Scotland)
An analysis of the epitope knowledge related to Mycobacteria.
Immunome research
Codominance of TLR2-dependent and TLR2-independent modulation of MHC class II in Mycobacterium tuberculosis infection in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Genomics and the evolution, pathogenesis, and diagnosis of tuberculosis.
The Journal of clinical investigation
LspA-independent action of globomycin on Mycobacterium tuberculosis.
The Journal of antimicrobial chemotherapy
Regulation of Mycobacterium tuberculosis whiB3 in the mouse lung and macrophages.
Infection and immunity
Potent inhibition of macrophage responses to IFN-gamma by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2.
Journal of immunology (Baltimore, Md. : 1950)
GTP-dependent secretion from neutrophils is regulated by Cdk5.
The Journal of biological chemistry
CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950)
Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent mechanisms.
Journal of immunology (Baltimore, Md. : 1950)
Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950)
Mycobacterium tuberculosis exerts gene-selective inhibition of transcriptional responses to IFN-gamma without inhibiting STAT1 function.
Journal of immunology (Baltimore, Md. : 1950)
Mechanisms of cell recruitment in the immune response to Mycobacterium tuberculosis.
Microbes and infection
Cholesterol esterification by host and parasite is essential for optimal proliferation of Toxoplasma gondii.
The Journal of biological chemistry
Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America
Bacterial inhibition of phagocytosis.
Cellular microbiology
GTP-dependent permeabilized neutrophil secretion requires a freely diffusible cytosolic protein.
Journal of cellular biochemistry
Phagocytosis of crocidolite asbestos induces oxidative stress, DNA damage, and apoptosis in mesothelial cells.
American journal of respiratory cell and molecular biology
Immune responses in tuberculosis.
Current opinion in immunology
Toward the development of antibacterial vaccines: report of a symposium and workshop. Organizing Committee.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1.
Journal of immunology (Baltimore, Md. : 1950)
Editorial response: variation in clinical and immune responses to bacille Calmette-Guérin--implications for an improved tuberculosis vaccine.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Preparation and characterization of an endogenously fluorescent annexin for detection of apoptotic cells.
Analytical biochemistry
Roles of calcium and annexins in phagocytosis and elimination of an attenuated strain of Mycobacterium tuberculosis in human neutrophils.
Microbial pathogenesis
Macrophage receptors for Mycobacterium tuberculosis.
Infection and immunity
Calcium-dependent neutrophil secretion: characterization and regulation by annexins.
Journal of immunology (Baltimore, Md. : 1950)
Crocidolite asbestos induces apoptosis of pleural mesothelial cells: role of reactive oxygen species and poly(ADP-ribosyl) polymerase.
Environmental health perspectives
Transfer of phagocytosed particles to the parasitophorous vacuole of Leishmania mexicana is a transient phenomenon preceding the acquisition of annexin I by the phagosome.
Journal of cell science
Selective receptor blockade during phagocytosis does not alter the survival and growth of Mycobacterium tuberculosis in human macrophages.
American journal of respiratory cell and molecular biology
Asbestos induces apoptosis of human and rabbit pleural mesothelial cells via reactive oxygen species.
The Journal of clinical investigation
The (alpha2-->8)-linked polysialic acid capsule of group B Neisseria meningitidis modifies multiple steps during interaction with human macrophages.
Infection and immunity
Phagosome-lysosome fusion is a calcium-independent event in macrophages.
The Journal of cell biology
Mobilization of annexin V during the uptake of DNP-albumin by human dendritic cells.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
A fluorometric assay for the quantification of RNA in solution with nanogram sensitivity.
Analytical biochemistry
Calcium signalling initiated by CR1 (CD35) crosslinking is mediated by phagocyte Fc gamma receptors in cis.
Biochemical and biophysical research communications
Annexin expression in human dendritic cells.
Advances in experimental medicine and biology
Selective translocation of annexins III, IV, and V during intracellular redistribution of Chlamydia trachomatis serovar L2 in HeLa and McCoy cells.
Annals of the New York Academy of Sciences
Annexins possess functionally distinguishable Ca2+ and phospholipid binding domains.
Biochemical and biophysical research communications
Selective translocation of annexins during intracellular redistribution of Chlamydia trachomatis in HeLa and McCoy cells.
Infection and immunity
Epitope mapping of annexin I: antibodies that compete with phospholipids and calcium recognize amino acids 42-99.
The Biochemical journal
Annexin III translocates to the periphagosomal region when neutrophils ingest opsonized yeast.
Journal of immunology (Baltimore, Md. : 1950)
Identification of a domain that mediates vesicle aggregation reveals functional diversity of annexin repeats.
The Journal of biological chemistry
Purification and characterization of an abundant cytosolic protein from human neutrophils that promotes Ca2(+)-dependent aggregation of isolated specific granules.
The Journal of clinical investigation
Characterization of Ca2(+)-dependent phospholipid binding, vesicle aggregation and membrane fusion by annexins.
The Biochemical journal
Use of a novel strategy for the preparation and characterization of an antipeptide antibody capable of recognizing members of the annexin family.
Biochemical and biophysical research communications
Synexin-like proteins from human polymorphonuclear leukocytes. Identification and characterization of granule-aggregating and membrane-fusing activities.
The Journal of biological chemistry
Human polymorphonuclear leukocytes contain synexin, a calcium-binding protein that mediates membrane fusion.
Transactions of the Association of American Physicians
Complement (C5)-derived chemotactic activity accounts for accumulation of polymorphonuclear leukocytes in cerebrospinal fluid of rabbits with pneumococcal meningitis.
Infection and immunity
Correlation of in vitro time-kill curves and kinetics of bacterial killing in cerebrospinal fluid during ceftriaxone therapy of experimental Escherichia coli meningitis.
Antimicrobial agents and chemotherapy
Combination antifungal chemotherapy for experimental disseminated candidiasis: lack of correlation between in vitro and in vivo observations with amphotericin B and rifampin.
Reviews of infectious diseases
Experimental pneumococcal meningitis: role of leukocytes in pathogenesis.
Infection and immunity
Inhibition of isolation of Escherichia coli in blood cultures by trimethoprim-sulfamethoxazole.
The Journal of infectious diseases
Antibiotic combinations in experimental infections in animals.
Reviews of infectious diseases
Affiliation