Assoc Professor in Residence
M_PEDS-GASTROENTEROLOGY
+1 415 502-2352
As a pediatric gastroenterologist and physician scientist, I am keenly aware of the challenges faced by our pediatric population. The intestinal epithelium comprises the human body’s greatest environmentally exposed surface and is the largest sensory and endocrine organ. My research utilizes human intestinal organoids and animal models to understand how the intestine senses and responds to both regular and inflammatory stimuli. By investigating the molecular pathways involved, we aim to discover new ways to promote intestinal wound healing and modulate the signals contributing to visceral pain syndromes.
Publications
A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance.
Proceedings of the National Academy of Sciences of the United States of America
SPARC - Mapping Gut-Spinal Cord Connections in Visceral Pain.
The FASEB Journal
948 – Nuclear Receptor Liver Receptor Homolog-1 Promotes Intestinal Notch Signaling and Enteroendocrine Cell Development.
Gastroenterology
Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones.
Nature communications
Advances in Enteric Neurobiology: The "Brain" in the Gut in Health and Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival.
Nature communications
273 - Nuclear Receptor LRH-1 Mitigates Intestinal Inflammatory Disease by Promoting Stem Cell Survival and Directing Normal Epithelial Composition.
Gastroenterology
Intestinal Organoids: New Frontiers in the Study of Intestinal Disease and Physiology.
Journal of pediatric gastroenterology and nutrition
Tu1824 Targeting Intestinal Stem Cells to Promote Healing in Inflammatory Bowel Disease.
Gastroenterology
Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs.
Proceedings of the National Academy of Sciences of the United States of America
Sa1803 Dissecting the Oncogenic Activity of the Nuclear Receptor LRH-1 in the Colon.
Gastroenterology
Doublesex and the regulation of sexual dimorphism in Drosophila melanogaster: structure, function, and mutagenesis of a female-specific domain.
The Journal of biological chemistry
Dimerization of doublesex is mediated by a cryptic ubiquitin-associated domain fold: implications for sex-specific gene regulation.
The Journal of biological chemistry
Expression, crystallization and preliminary X-ray characterization of the Drosophila transcription factor Doublesex.
Acta crystallographica. Section D, Biological crystallography
Affiliation